Found in MOPAC's galleries are works by 11 of the country’s national artists for visual arts: Fernando Amorsolo (proclaimed in 1972), Carlos “Botong” Francisco (1972), Victorio Edades (1976), Vicente Manansala (1981), Cesar Legaspi (1990), Hernando Ocampo (1991), Arturo Luz (1997), Jeremias Elizalde Navarro (1997), Ang Kiukok (2001), Federico Aguilar Alcuaz (2009) and Jose Joya (2003).
The artworks of Presidential Medal of Merit awardees such as Anita Magsaysay-Ho and Mauro “Malang” Santos are given prominence in the first building of the museum. In the second building are arrays of metal-age pottery, sculptures of santo (saints), excavated Chinese trade wares, Spanish-era jewelry, prewar furniture, and tribal cultural objects from the Cordilleras and Mindanao.